Original and Review Articles
2023
Balasubramanian, S., Haneen, M. A., Sharma, G., & Perumal, E. (2024). Acute copper
oxide nanoparticles exposure alters zebrafish larval microbiome. Life Sciences, 336,
122313. Impact Factor:6.1
Manoharan, S., Prajapati, K., & Perumal, E. (2023). Natural bioactive compounds and
FOXO3a in cancer therapeutics: An update. Fitoterapia, 105807. Impact Factor:3.4
Manoharan, S., Saha, S., Murugesan, K., Santhakumar, A., & Perumal, E. (2023). Natural
bioactive compounds and STAT3 against hepatocellular carcinoma: An update. Life
Sciences, 122351. Impact Factor:6.1
Ottappilakkil, H., Ottoor, A., Manoharan, S., Balasubramanian, M., & Perumal, E. (2023).
Fluoride Binding Potential of Selected Phytochemicals: A Pilot
Study. Environmental Science and Pollution Research, 30(45), 101888-101895. Impact Factor:5.8
Balasubramanian, S., Rangasamy, S., Vivekanandam, R., & Perumal, E. (2023). Acute
exposure to tenorite nanoparticles induces phenotypic and behavior alterations in
zebrafish larvae. Chemosphere, 339, 139681. Impact Factor: 8.8
Balasubramanian, S., Duraikannan, V., & Perumal, E. (2023). Toxicogenomic analysis of
physiologically important metals: An integrated in silico approach. Food and
Chemical Toxicology, 113895. Impact Factor:4.3
Manoharan, S., Prajapati, K., Karthikeyan, T., Vedagiri, H., & Perumal, E. (2023). Virtual
screening of FOXO3a activators from natural product-like compound
library. Molecular Diversity, 1-16. Impact Factor:3.9
Bhattacharjee, M., Manoharan, S., Sathisaran, U., Tamatam, A., & Perumal, E. (2023).
MAO inhibiting phytochemicals from the roots of Glycyrrhiza glabra L. Journal of
Biomolecular Structure and Dynamics, 1-19. Impact Factor:4.4
Manoharan, S., Vedagiri, H., & Perumal, E. (2023). Potent FOXO3a activators from
biologically active compound library for cancer therapeutics: an in silico
approach. Applied Biochemistry and Biotechnology, 1-24. Impact Factor: 3.1
Anilkumar, A. T., Manoharan, S., Balasubramanian, S., & Perumal, E. (2023). Garcinia
gummi‐gutta: Phytochemicals and pharmacological applications. BioFactors. Impact Factor:
Bhattacharjee, M., Manoharan, S., Deshetty, U. M., & Perumal, E. (2023). Acute
hypobaric hypoxia exposure causes neurobehavioral impairments in rats: Role of
brain catecholamines and tetrahydrobiopterin alterations. Neurochemical
Research, 48(2), 471-486. Impact Factor:4.414
2022
Manoharan, S., Deivendran, B., & Perumal, E. (2022). Chemotherapeutic Potential of
Saikosaponin D: Experimental Evidence. Journal of Xenobiotics 12(4), 378-405.Impact Factor:6.8
Balasubramanian, S., & Perumal, E. (2022). A systematic review on fluoride-induced
epigenetic toxicity in mammals. Critical Reviews in Toxicology, 1-20.Impact Factor:
Manoharan, S., & Perumal, E. (2022). Potential role of Marine Bioactive Compounds
targeting signaling pathways in cancer: A review. European Journal of
Pharmacology, 175330.Impact Factor:5.195
Babu, S., Manoharan, S., Ottappilakkil, H., & Perumal, E. (2022). Role of oxidative
stress-mediated cell death and signaling pathways in experimental fluorosis.
Chemico-Biological Interactions, 110106.Impact Factor:5.168
Manoharan, S., Balakrishnan, A., Hemamalini, V., & Perumal, E. (2022). Screening of
potent STAT3-SH2 domain inhibitors from JAK/STAT compound library through
molecular dynamics simulation.Molecular Diversity, 1-12.Impact Factor:3.9
Ottappilakkil, H., Babu, S., Balasubramanian, S., Manoharan, S., & Perumal, E.(2022).
Fluoride Induced Neurobehavioral Impairments in Experimental Animals: a Brief
Review. Biological Trace Element Research, 1-23.Impact Factor:3.45
2021
Sundarraj, K., Raghunath, A., Panneerselvam, L., & Perumal, E. (2021). Fisetin inhibits
autophagy in HepG2 cells via PI3K/Akt/mTOR and AMPK pathway. Nutrition and
cancer, 73(11-12), 2502-2514.Impact Factor:2.0
Balasubramanian, S., & Perumal, E. (2021). Integrated in silico analysis for the
identification of key genes and signaling pathways in copper oxide nanoparticles
toxicity. Toxicology, 463, 152984.Impact Factor:4.8
Thirumurthi, N. A., Raghunath, A., Balasubramanian, S., & Perumal, E. (2021).
Evaluation of maghemite nanoparticles–induced developmental toxicity and
oxidative stress in zebrafish embryos/larvae. Biological Trace Element Research,
200(5), 2349-2364.Impact Factor:3.45
Perumal, E., Eswaran, S., Parvin, R., & Balasubramanian, S. (2021). Mitigation of arsenic
induced developmental cardiotoxicity by ferulic acid in zebrafish. Comparative
Biochemistry and Physiology Part C: Toxicology & Pharmacology, 244, 109021.Impact Factor:3.9
2020
Parthasarathy, A., Vijayakumar, S., Malaikozhundan, B., Thangaraj, M. P., Perumal, E.,
Murugan, T., ... & Vaseeharan, B. (2020). Chitosan-coated silver nanoparticles
promoted antibacterial, antibiofilm, wound-healing of murine macrophages and
antiproliferation of human breast cancer MCF 7 cells. Polymer Testing, 90, 106675 [Epub ahead of print]. Impact Factor:5.0
Balasubramanian, S., Raghunath, A., & Perumal, E. (2020). Nanoengineered biomaterials
for neurodegenerative disorders. Nanoengineered Biomaterials for Advanced Drug
Delivery, 713-734. [Epub ahead of print]. Impact Factor:
Balasubramanian, S., Gunasekaran, K., Sasidharan, S., Mathan, V. J., & Perumal, E.
(2020). MicroRNAs and xenobiotic toxicity: an overview. Toxicology reports, 7,
583-595. [Epub ahead of print]. Impact Factor:
Raghunath, A., Nagarajan, R., & Perumal, E. (2020). ZFARED: a database of the
antioxidant response elements in zebrafish. Current Bioinformatics, 15(5), 415-419.
Tharmalingam, B., Mathivanan, M., Mani, K. S., Kaminsky, W., Raghunath, A., Jothi, M.,
... & Murugesapandian, B. (2020). Selective detection of pyrophosphate anion by
zinc ensemble of C3-symmetric triaminoguanidine-pyrrole conjugate and its
biosensing applications. Analytica Chimica Acta, 1103, 192-201. [Epub ahead of print]. Impact Factor:6.558
Deshetty, U. M., Tamatam, A., Bhattacharjee, M.,Perumal, E., Natarajan, G., & Khanum,
F. (2020). Ameliorative effect of hesperidin against motion sickness by modulating
histamine and histamine H1 receptor expression. Neurochemical Research, 45(2),
371-384 [Epub ahead of print]. Impact Factor:4.4
Sundarraj, K., Raghunath, A., Panneerselvam, L., Perumal, E. (2019).
Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells.
Biofactors doi: 10.1002/biof.1577. [Epub ahead of print]. Impact Factor: 3.598
2019
Sundarraj, K., Raghunath, A., Panneerselvam, L., Perumal, E. (2019).
Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells.
Biofactors doi: 10.1002/biof.1577. [Epub ahead of print]. Impact Factor: 3.598
Panneerselvam, L., Raghunath, A., Ravi, M.S., Vetrivel, A., Subramaniam, V., Sundarraj, K., Perumal, E. (2019).
Ferulic acid attenuates arsenic-induced cardiotoxicity in rats.
Biotechnol Appl Biochem doi: 10.1002/bab.1830. [Epub ahead of print]. Impact Factor: 1.559
Panneerselvam, L., Raghunath, A., Sundarraj, K., Perumal, E. (2019).
Acute fluoride exposure alters myocardial redox and inflammatory markers in rats.
Mol Biol Rep doi: 10.1007/s11033-019-05050-9. [Epub ahead of print]. Impact Factor: 2.107
Balasubramanian, S., Raghunath, A., Perumal, E. (2019).
Role of epigenetics in zerafish development.
Gene doi: 10.1016/j.gene.2019.144049. [Epub ahead of print]. Impact Factor: 2.638
Mani, R., Balasubramanian, S., Raghunath, A., Perumal, E. (2019).
Chronic exposure to copper oxide nanoparticles causes muscle toxicity in adult zebrafish.
Environ Sci Pollut Res Int doi: 10.1007/s11356-019-06095-w. [Epub ahead of print]. Impact Factor: 2.914
Raghunath, A., Nagarajan, R., Sundarraj, K., Palanisamy, K., Perumal, E. (2019).
Identification of compounds that inhibit the binding of Keap1a/Keap1b Kelch DGR domain with Nrf2 ETGE/DLG motifs in zebrafish.
Basic Clin Pharmacol Toxicol 125(3):259-270. Impact Factor: 2.452
Manickam, V., Dhakshinamoorthy, V., Perumal, E. (2019).
Iron oxide nanoparticles affects behaviour and monoamine levels in mice.
Neurochem Res 44(7):1533-1548. Impact Factor: 2.782
Bhattacharjee, M., Perumal, E. (2019).
Potential plant-derived catecholaminergic activity enhancers for neuropharmacological approaches: A review.
Phytomedicine 53(4):169-186. Impact Factor: 4.180
2018
Raghunath, A., Sundarraj, K., Arfuso, F., Sethi, G., Perumal, E. (2018).
Dysregulation of Nrf2 in hepatocellular carcinoma: Role in cancer progression and chemoresistance.
Cancers 10(12). pii: E481. Impact Factor: 6.162
Raghunath, A., Nagarajan, R., Sundarraj, K., Panneerselvam, L., Perumal, E. (2018).
Genome-wide identification and analysis of Nrf2 binding sites - Antioxidant response elements in zebrafish.
Toxicol Appl Pharmacol 53(4):169-186. Impact Factor: 3.585
Ameeramja, J., Raghunath, A., Perumal, E. (2018).
Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats.
Environ Sci Pollut Res Int 25(26):26157-26166. Impact Factor: 2.914
Raghunath, A., Sundarraj, K., Nagarajan, R., Arfuso, F., Bian, J., Kumar, A.P., Sethi, G., Perumal, E. (2018).
Antioxidant response elements: Discovery, classes, regulation and potential applications.
Redox Biol 17:297-314. Impact Factor: 7.793
Ameeramja, J., Kanagaraj, V.V., Perumal, E. (2018).
Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats.
Food Chem Toxicol 118:235-244. Impact Factor: 3.775
Ameeramja, J., Perumal, E. (2018).
Possible modulatory effect of tamarind seed coat extract on fluoride-induced pulmonary inflammation and fibrosis in rats.
Inflammation 41(3):886-895. Impact Factor: 2.939
Manickam, V., Dhakshinamoorthy, V., Perumal, E. (2018).
Iron oxide nanoparticles induces cell cycle-dependent neuronal apoptosis in mice.
J Mol Neurosci 64(3):352-362. Impact Factor: 2.577
Sundarraj, K, Raghunath, A., Perumal, E. (2018).
A review on the chemotherapeutic potential of fisetin: In vitro evidences.
Biomed Pharmacother 97:928-940. Impact Factor: 3.743
2017
Manickam, V., Periyasamy, M., Dhakshinamoorthy, V., Panneerselvam, L., Perumal, E. (2017).
Recurrent exposure to ferric oxide nanoparticles alters myocardial oxidative stress, apoptosis and necrotic markers in male mice.
Chem Biol Interact 278:54-64. Impact Factor: 3.407
Ameeramja, J., Perumal, E. (2017).
Pulmonary fluorosis: a review.
Environ Sci Pollut Res Int 24(28):22119-22132. Impact Factor: 2.914
Panneerselvam, L., Raghunath, A., Perumal, E. (2017).
Differential expression of myocardial heat shock proteins in rats acutely exposed to fluoride.
Cell Stress Chaperones 22(5):743-750. Impact Factor: 2.903
Dhakshinamoorthy, V., Manickam, V., Perumal, E. (2017).
Neurobehavioural Toxicity of Iron Oxide Nanoparticles in Mice.
Neurotox Res 32(2):187-203. Impact Factor: 3.311
Sundarraj, K., Raghunath, A., Panneerselvam, L., Perumal, E. (2017).
Iron oxide nanoparticles modulate heat shock proteins and organ specific markers expression in mice male accessory organs.
Toxicol Appl Pharmacol 317:12-24. Impact Factor: 3.585
Ameeramja, J., Perumal, E. (2017).
Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells.
Food Chem Toxicol 109(Pt 2):941-950. Impact Factor: 3.775
Panneerselvam, L., Raghunath, A., Perumal, E. (2017).
Acute fluoride poisoning alters myocardial cytoskeletal and AMPK signaling proteins in rats.
Int J Cardiol 229:96-101. Impact Factor: 3.471
Raghunath, A., Perumal, E. (2017).
Metal oxide nanoparticles as antimicrobial agents: a promise for the future.
Int J Antimicrob Agents 49:137-152. Impact Factor: 4.615
Sundarraj, K., Manickam, V., Raghunath, A., Periyasamy, M., Viswanathan, M. P., Perumal, E. (2017).
Repeated exposure to iron oxide nanoparticles causes testicular toxicity in mice.
Environ Toxicol 32:594-608. Impact Factor: 2.649
Vijayakumar, S., Vaseeharan, B., Malaikozhundan, B., Gopi, N., Ekambaram, P.,
Pachaiappan, R., Velusamy, P., Murugan, K., Benelli, G., Suresh Kumar, R.,
Suriyanarayanamoorthy.(2017).
Therapeutic effects of gold nanoparticles synthesized using Musa paradisiaca peel extract
against multiple antibiotic resistant Enterococcus faecalis biofilms and human lung
cancer cells (A549).
Microb Pathog 102:173-183. Impact Factor: 2.581
2016
Raghunath, A., Jeyabaskar, D., Sundarraj, K., Panneerselvam, L., Perumal, E. (2016).
In silico prediction of microRNAs on fluoride induced sperm toxicity in mice.
Food Chem Toxicol 98(Pt A):34-49. Impact Factor: 3.775
Manju, S., Malaikozhundan, B., Vijayakumar, S., Shanthi, S., Jaishabanu, A., Ekambaram, P., Vaseeharan, B. (2016).
Antibacterial, antibiofilm and cytotoxic effects of Nigella sativa essential oil coated gold nanoparticles.
Microb Pathog 91:129-35. Impact Factor: 2.581
Ganesan, S., Anaimalai Thirumurthu, N., Raghunath, A., Vijayakumar, S., Perumal, E. (2016).
Acute and sub-lethal exposure to copper oxide nanoparticles causes oxidative stress and teratogenicity in zebrafish embryos.
J Appl Toxicol 36(4):554-567. Impact Factor: 3.065
Ameeramja, J., Panneerselvam, L., Govindarajan, V., Jeyachandran, S., Baskaralingam, V., Perumal, E. (2016).
Tamarind seed coat ameliorates fluoride induced cytotoxicity, oxidative stress, mitochondrial dysfunction and apoptosis in A549 cells.
J Hazard Mater 15(301):554-565. Impact Factor: 7.650
2015
Panneerselvam, L., Govindarajan, V., Ameeramja, J., Nair, H.R., Perumal, E. (2015).
Single oral acute fluoride exposure causes changes in cardiac expression of oxidant and antioxidant enzymes, apoptotic and necrotic markers in male rats.
Biochimie 119:27-35. Impact Factor: 3.362
Kanagaraj, V.V., Panneerselvam, L., Govindarajan, V., Ameeramja, J., Perumal, E. (2015).
Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: A possible mechanism.
Biofactors 41(2):90-100. Impact Factor: 3.598
Raghunath, A., Perumal, E. (2015).
Micro-RNAs and their roles in eye disorders.
Ophthalmic Res 53(4):169-186. Impact Factor: 1.685
2014
Purushothaman, S., Raghunath, A., Dhakshinamoorthy, V., Panneerselvam, L., Perumal, E. (2014).
Acute exposure to titanium dioxide (TiO2) induces oxidative stress in zebrafish gill tissues.
Toxicol Environ Chem 96(6):890-905. Impact Factor: 0.971
2013
Aruljothi, S., Ser, Y.L., Peramaiyan, R., Kanjoormana, A.M., Perumal, E., Feng, L.,Muthu, K.S., Kodappully, S.S.,
Joo-In, P., Kwang, S.A., Kam, M.H., Alan, P.K., Gautam, S. (2013).
An anthraquinone derivative, emodin sensitized hepatocellular carcinoma cells to TRAIL induced apoptosis
through the induction of death receptors and downregulation of cell survival proteins.
Apoptosis 18:1175-1187. Impact Factor: 4.021
Aruljothi, S., Muthu, K.S., Tina, H.O., Feng, L., Perumal, E., Luxi, C., Shireen, V., Taher, A., Shweta, K.,
Kwang, S.A., Alan, P.K., Kam, M.H., Gautam, S. (2013).
Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation
of STAT3.
Br J Pharmacol 170: 807-821. Impact Factor: 6.583
Aruljothi, S., Shanmugam, M.K., Perumal, E., Li, F., Nachiyappan, A., Dai, X., Swamy, S.N., Ahn, K.S.,
Kumar, A.P., Tan, B.K., Hui, K.M., Sethi, G. (2013).
Potential role of signal transducer and activator of transcription (STAT3) singaling pathway in inflammation,
survival, proliferation and invasion of hepatocellular carcinoma.
Biochim Biphys Acta 1835(1):46-60. Impact Factor: 6.887
Manu, K.A., Shanmugam, M.K., Ong, T.H., Aruljothi, S., Siveen, K.S., Perumal, E., Samy, R.P., Bist,P. Lim, L.H.,
Kumar, A.P., Hui, K.M., Sethi, G. (2013).
Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthoptic model of
human hepatocellular carcinoma.
PLoS One 8(3):e57015. Impact Factor: 2.776
Perumal, E., Vanaja, P., Vimal, G., Lakshmikanthan, P. (2013).
A brief review on experimental fluorosis.
Toxicol Lett 223:236-251. Impact Factor: 3.499
2011
Vanaja, P., Ekambaram, P. (2011).
Involvement of nitric oxide in learning and memory processes.
Indian J Med Res 133(5):471-478. Impact Factor: 1.251
2010
Ekambaram, P., Namitha, T., Bhuvaneswari, S., Aruljothi, S., Vasanth, D., Saravanakumar, M. (2010).
Therapeutic efficacy of Tamarindus indica (L) to protect against fluoride-induced oxidative stress in the liver
of female rats.
Fluoride 43(2):134-140. Impact Factor: 1.438
2005
Paul, V., Ekambaram, P. (2005).
Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain
and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.
Pharmacol Biochem Behav 80(3).363-370. Impact Factor: 2.773
Paul, V., Reddy, L., Ekambaram, P. (2005).
A reversal by L-arginine and sodium nitroprusside of ageing-induced memory impairment in rats by increasing
nitric oxide concentration in the hippocampus.
Indian J Physiol Pharmacol 49(2):179-186. Impact Factor: 0.000
2004
Paul, V., Reddy, L., Ekambaram, P. (2004).
The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after
the injection of picrotoxin.
Indian J Physiol Pharmacol 48(2):191-198. Impact Factor: 0.000
Vanaja, P., Ekambaram, P. (2004).
Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsion,
memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats.
Pharmacol Biochem Behav 77(1):1-8. Impact Factor: 2.773
2003
Paul, V., Ekambaram, P. (2003).
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced
convulsions in rats.
Indian J Physiol Pharmacol 47(4): 400-406. Impact Factor: 0.000
Ekambaram, P., Paul, V. (2003).
Effect of vitamin D on chronic behavioural and dental toxicities of sodium fluoride in rats.
Fluoride 36(2):189-197. Impact Factor: 1.438
Paul, V., Reddy, L., Ekambaram, P. (2003).
Prevention of picrotoxin convulsions-induced learning and memory impairment by nitric acid
increasing dose of L-arginine in rats.
Pharmacol Biochem Behav 75:329-334. Impact Factor: 2.773
2002
Ekambaram, P., Paul, V. (2002).
Modulation of fluoride in rats by calcium carbonate and by withdrawal of fluoride exposure.
Pharmacol Toxicol 90(2):53-58. Impact Factor: 2.452
2001
Ekambaram, P., Paul, V. (2001).
Calcium preventing locomotor behavioral and dental toxicities by decreasing serum fluoride level in rats.
Environ Toxicol Pharmacol 9(4):141-146. Impact Factor: 3.061
1998
Paul, V., Ekambaram, P., Jayakumar, A. R. (1998).
Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats.
Environ Toxicol Pharmacol 6(3):187-191. Impact Factor: 3.061
Book Chapters
Velankanni, P., Balasubramanian, S., Raghunath, A., Arfuso, G, Sethi, G., Perumal, E. (2019).
Curcumin as a potential therapeutic for Alzheimer’s disease: A multi-targeted approach. In: M. K. Swamy, J. K . Patra, G. R. Rudramurthy (eds.).
Medicinal Plants: Chemistry, Pharmacology, and Therapeutic Applications 79-102.
CRC Press, Taylor and Francis Group.
Panneerselvam, L., Raghunath, A., Sundarraj, K., Perumal, E. (2018).
HO-1/HSP32 and cardiac stress signaling. In: A.A.A. Asea, P. Kaur (eds.).
Heat Shock Proteins in Signaling Pathways
Vol. 17, 139-160.
Springer International Publishing AG.
Raghunath, A., Panneerselvam, L., Sundarraj, K., Perumal, E. (2018).
Heat shock proteins and endoplasmic reticulum stress. In: A.A.A. Asea, P. Kaur (eds.).
Heat Shock Proteins and Stress
Vol. 15, 39-78.
Springer International Publishing AG.
Raghunath, A., Perumal, E. (2018).
Analysis of lethalith and malformations during zebrafish
(Danio rerio) development. In: Luis Felix (ed.).
Teratogenicity Testing: Methods and Protocols, Methods in Molecular Biology
Vol. 1997, 337-363.
Humana Press, New York, NY.
Raghunath, A., Sundarraj, K., Kanagaraj, V.V., Perumal, E. (2018).
Plant sources as potential therapeutics for Alzheimer's disease. In: Parimelazhagan
Thangaraj (ed.). Medicinal Plants: Promising Future for Health and New Drugs 162-192.
CRC Press, Taylor and Francis Group.
Subramaniam, A., Shanmugam, M.K., Perumal, E., Nachiyappan, A., Kumar, A.P.,
Tan, B. K. H., Sethi, G. (2014).
Possible involvement of signal transducer and activator of transcription-3 (STAT3)
signaling pathway in the initiation and progression of hepatocellular carcinoma. In:
R. Sudhakaran P. (eds).
Perspectives in Cancer Prevention-Translational Cancer Research 73-87. Springer, New Delhi.
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