Publications

Connaître, découvrir, communiquer—telle est, au fond, notre honorable destinée.
To get to know, to discover, to publish—this is the destiny of a scientist.
            — Francois Arago

Original and Review Articles


2019

Sundarraj, K., Raghunath, A., Panneerselvam, L., Perumal, E. (2019). Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells. Biofactors doi: 10.1002/biof.1577. [Epub ahead of print]. Impact Factor: 3.598

Panneerselvam, L., Raghunath, A., Ravi, M.S., Vetrivel, A., Subramaniam, V., Sundarraj, K., Perumal, E. (2019). Ferulic acid attenuates arsenic-induced cardiotoxicity in rats. Biotechnol Appl Biochem doi: 10.1002/bab.1830. [Epub ahead of print]. Impact Factor: 1.559

Panneerselvam, L., Raghunath, A., Sundarraj, K., Perumal, E. (2019). Acute fluoride exposure alters myocardial redox and inflammatory markers in rats. Mol Biol Rep doi: 10.1007/s11033-019-05050-9. [Epub ahead of print]. Impact Factor: 2.107

Balasubramanian, S., Raghunath, A., Perumal, E. (2019). Role of epigenetics in zerafish development. Gene doi: 10.1016/j.gene.2019.144049. [Epub ahead of print]. Impact Factor: 2.638

Mani, R., Balasubramanian, S., Raghunath, A., Perumal, E. (2019). Chronic exposure to copper oxide nanoparticles causes muscle toxicity in adult zebrafish. Environ Sci Pollut Res Int doi: 10.1007/s11356-019-06095-w. [Epub ahead of print]. Impact Factor: 2.914

Raghunath, A., Nagarajan, R., Sundarraj, K., Palanisamy, K., Perumal, E. (2019). Identification of compounds that inhibit the binding of Keap1a/Keap1b Kelch DGR domain with Nrf2 ETGE/DLG motifs in zebrafish. Basic Clin Pharmacol Toxicol 125(3):259-270. Impact Factor: 2.452

Manickam, V., Dhakshinamoorthy, V., Perumal, E. (2019). Iron oxide nanoparticles affects behaviour and monoamine levels in mice. Neurochem Res 44(7):1533-1548. Impact Factor: 2.782

Bhattacharjee, M., Perumal, E. (2019). Potential plant-derived catecholaminergic activity enhancers for neuropharmacological approaches: A review. Phytomedicine 53(4):169-186. Impact Factor: 4.180

2018

Raghunath, A., Sundarraj, K., Arfuso, F., Sethi, G., Perumal, E. (2018). Dysregulation of Nrf2 in hepatocellular carcinoma: Role in cancer progression and chemoresistance. Cancers 10(12). pii: E481. Impact Factor: 6.162

Raghunath, A., Nagarajan, R., Sundarraj, K., Panneerselvam, L., Perumal, E. (2018). Genome-wide identification and analysis of Nrf2 binding sites - Antioxidant response elements in zebrafish. Toxicol Appl Pharmacol 53(4):169-186. Impact Factor: 3.585

Ameeramja, J., Raghunath, A., Perumal, E. (2018). Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats. Environ Sci Pollut Res Int 25(26):26157-26166. Impact Factor: 2.914

Raghunath, A., Sundarraj, K., Nagarajan, R., Arfuso, F., Bian, J., Kumar, A.P., Sethi, G., Perumal, E. (2018). Antioxidant response elements: Discovery, classes, regulation and potential applications. Redox Biol 17:297-314. Impact Factor: 7.793

Ameeramja, J., Kanagaraj, V.V., Perumal, E. (2018). Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol 118:235-244. Impact Factor: 3.775

Ameeramja, J., Perumal, E. (2018). Possible modulatory effect of tamarind seed coat extract on fluoride-induced pulmonary inflammation and fibrosis in rats. Inflammation 41(3):886-895. Impact Factor: 2.939

Manickam, V., Dhakshinamoorthy, V., Perumal, E. (2018). Iron oxide nanoparticles induces cell cycle-dependent neuronal apoptosis in mice. J Mol Neurosci 64(3):352-362. Impact Factor: 2.577

Sundarraj, K, Raghunath, A., Perumal, E. (2018). A review on the chemotherapeutic potential of fisetin: In vitro evidences. Biomed Pharmacother 97:928-940. Impact Factor: 3.743

2017

Manickam, V., Periyasamy, M., Dhakshinamoorthy, V., Panneerselvam, L., Perumal, E. (2017). Recurrent exposure to ferric oxide nanoparticles alters myocardial oxidative stress, apoptosis and necrotic markers in male mice. Chem Biol Interact 278:54-64. Impact Factor: 3.407

Ameeramja, J., Perumal, E. (2017). Pulmonary fluorosis: a review. Environ Sci Pollut Res Int 24(28):22119-22132. Impact Factor: 2.914

Panneerselvam, L., Raghunath, A., Perumal, E. (2017). Differential expression of myocardial heat shock proteins in rats acutely exposed to fluoride. Cell Stress Chaperones 22(5):743-750. Impact Factor: 2.903

Dhakshinamoorthy, V., Manickam, V., Perumal, E. (2017). Neurobehavioural Toxicity of Iron Oxide Nanoparticles in Mice. Neurotox Res 32(2):187-203. Impact Factor: 3.311

Sundarraj, K., Raghunath, A., Panneerselvam, L., Perumal, E. (2017). Iron oxide nanoparticles modulate heat shock proteins and organ specific markers expression in mice male accessory organs. Toxicol Appl Pharmacol 317:12-24. Impact Factor: 3.585

Ameeramja, J., Perumal, E. (2017). Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells. Food Chem Toxicol 109(Pt 2):941-950. Impact Factor: 3.775

Panneerselvam, L., Raghunath, A., Perumal, E. (2017). Acute fluoride poisoning alters myocardial cytoskeletal and AMPK signaling proteins in rats. Int J Cardiol 229:96-101. Impact Factor: 3.471

Raghunath, A., Perumal, E. (2017). Metal oxide nanoparticles as antimicrobial agents: a promise for the future. Int J Antimicrob Agents 49:137-152. Impact Factor: 4.615

Sundarraj, K., Manickam, V., Raghunath, A., Periyasamy, M., Viswanathan, M. P., Perumal, E. (2017). Repeated exposure to iron oxide nanoparticles causes testicular toxicity in mice. Environ Toxicol 32:594-608. Impact Factor: 2.649

Vijayakumar, S., Vaseeharan, B., Malaikozhundan, B., Gopi, N., Ekambaram, P., Pachaiappan, R., Velusamy, P., Murugan, K., Benelli, G., Suresh Kumar, R., Suriyanarayanamoorthy.(2017). Therapeutic effects of gold nanoparticles synthesized using Musa paradisiaca peel extract against multiple antibiotic resistant Enterococcus faecalis biofilms and human lung cancer cells (A549). Microb Pathog 102:173-183. Impact Factor: 2.581

2016

Raghunath, A., Jeyabaskar, D., Sundarraj, K., Panneerselvam, L., Perumal, E. (2016). In silico prediction of microRNAs on fluoride induced sperm toxicity in mice. Food Chem Toxicol 98(Pt A):34-49. Impact Factor: 3.775

Manju, S., Malaikozhundan, B., Vijayakumar, S., Shanthi, S., Jaishabanu, A., Ekambaram, P., Vaseeharan, B. (2016). Antibacterial, antibiofilm and cytotoxic effects of Nigella sativa essential oil coated gold nanoparticles. Microb Pathog 91:129-35. Impact Factor: 2.581

Ganesan, S., Anaimalai Thirumurthu, N., Raghunath, A., Vijayakumar, S., Perumal, E. (2016). Acute and sub-lethal exposure to copper oxide nanoparticles causes oxidative stress and teratogenicity in zebrafish embryos. J Appl Toxicol 36(4):554-567. Impact Factor: 3.065

Ameeramja, J., Panneerselvam, L., Govindarajan, V., Jeyachandran, S., Baskaralingam, V., Perumal, E. (2016). Tamarind seed coat ameliorates fluoride induced cytotoxicity, oxidative stress, mitochondrial dysfunction and apoptosis in A549 cells. J Hazard Mater 15(301):554-565. Impact Factor: 7.650

2015

Panneerselvam, L., Govindarajan, V., Ameeramja, J., Nair, H.R., Perumal, E. (2015). Single oral acute fluoride exposure causes changes in cardiac expression of oxidant and antioxidant enzymes, apoptotic and necrotic markers in male rats. Biochimie 119:27-35. Impact Factor: 3.362

Kanagaraj, V.V., Panneerselvam, L., Govindarajan, V., Ameeramja, J., Perumal, E. (2015). Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: A possible mechanism. Biofactors 41(2):90-100. Impact Factor: 3.598

Raghunath, A., Perumal, E. (2015). Micro-RNAs and their roles in eye disorders. Ophthalmic Res 53(4):169-186. Impact Factor: 1.685

2014

Purushothaman, S., Raghunath, A., Dhakshinamoorthy, V., Panneerselvam, L., Perumal, E. (2014). Acute exposure to titanium dioxide (TiO2) induces oxidative stress in zebrafish gill tissues. Toxicol Environ Chem 96(6):890-905. Impact Factor: 0.971

2013

Aruljothi, S., Ser, Y.L., Peramaiyan, R., Kanjoormana, A.M., Perumal, E., Feng, L.,Muthu, K.S., Kodappully, S.S., Joo-In, P., Kwang, S.A., Kam, M.H., Alan, P.K., Gautam, S. (2013). An anthraquinone derivative, emodin sensitized hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins. Apoptosis 18:1175-1187. Impact Factor: 4.021

Aruljothi, S., Muthu, K.S., Tina, H.O., Feng, L., Perumal, E., Luxi, C., Shireen, V., Taher, A., Shweta, K., Kwang, S.A., Alan, P.K., Kam, M.H., Gautam, S. (2013). Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. Br J Pharmacol 170: 807-821. Impact Factor: 6.583

Aruljothi, S., Shanmugam, M.K., Perumal, E., Li, F., Nachiyappan, A., Dai, X., Swamy, S.N., Ahn, K.S., Kumar, A.P., Tan, B.K., Hui, K.M., Sethi, G. (2013). Potential role of signal transducer and activator of transcription (STAT3) singaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. Biochim Biphys Acta 1835(1):46-60. Impact Factor: 6.887

Manu, K.A., Shanmugam, M.K., Ong, T.H., Aruljothi, S., Siveen, K.S., Perumal, E., Samy, R.P., Bist,P. Lim, L.H., Kumar, A.P., Hui, K.M., Sethi, G. (2013). Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthoptic model of human hepatocellular carcinoma. PLoS One 8(3):e57015. Impact Factor: 2.776

Perumal, E., Vanaja, P., Vimal, G., Lakshmikanthan, P. (2013). A brief review on experimental fluorosis. Toxicol Lett 223:236-251. Impact Factor: 3.499

2011

Vanaja, P., Ekambaram, P. (2011). Involvement of nitric oxide in learning and memory processes. Indian J Med Res 133(5):471-478. Impact Factor: 1.251

2010

Ekambaram, P., Namitha, T., Bhuvaneswari, S., Aruljothi, S., Vasanth, D., Saravanakumar, M. (2010). Therapeutic efficacy of Tamarindus indica (L) to protect against fluoride-induced oxidative stress in the liver of female rats. Fluoride 43(2):134-140. Impact Factor: 1.438

2005

Paul, V., Ekambaram, P. (2005). Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats. Pharmacol Biochem Behav 80(3).363-370. Impact Factor: 2.773

Paul, V., Reddy, L., Ekambaram, P. (2005). A reversal by L-arginine and sodium nitroprusside of ageing-induced memory impairment in rats by increasing nitric oxide concentration in the hippocampus. Indian J Physiol Pharmacol 49(2):179-186. Impact Factor: 0.000

2004

Paul, V., Reddy, L., Ekambaram, P. (2004). The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after the injection of picrotoxin. Indian J Physiol Pharmacol 48(2):191-198. Impact Factor: 0.000


Vanaja, P., Ekambaram, P. (2004). Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsion, memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats. Pharmacol Biochem Behav 77(1):1-8. Impact Factor: 2.773

2003

Paul, V., Ekambaram, P. (2003). Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats. Indian J Physiol Pharmacol 47(4): 400-406. Impact Factor: 0.000

Ekambaram, P., Paul, V. (2003). Effect of vitamin D on chronic behavioural and dental toxicities of sodium fluoride in rats. Fluoride 36(2):189-197. Impact Factor: 1.438

Paul, V., Reddy, L., Ekambaram, P. (2003). Prevention of picrotoxin convulsions-induced learning and memory impairment by nitric acid increasing dose of L-arginine in rats. Pharmacol Biochem Behav 75:329-334. Impact Factor: 2.773

2002

Ekambaram, P., Paul, V. (2002). Modulation of fluoride in rats by calcium carbonate and by withdrawal of fluoride exposure. Pharmacol Toxicol 90(2):53-58. Impact Factor: 2.452

2001

Ekambaram, P., Paul, V. (2001). Calcium preventing locomotor behavioral and dental toxicities by decreasing serum fluoride level in rats. Environ Toxicol Pharmacol 9(4):141-146. Impact Factor: 3.061

1998

Paul, V., Ekambaram, P., Jayakumar, A. R. (1998). Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats. Environ Toxicol Pharmacol 6(3):187-191. Impact Factor: 3.061

Book Chapters

Velankanni, P., Balasubramanian, S., Raghunath, A., Arfuso, G, Sethi, G., Perumal, E. (2019). Curcumin as a potential therapeutic for Alzheimer’s disease: A multi-targeted approach. In: M. K. Swamy, J. K . Patra, G. R. Rudramurthy (eds.). Medicinal Plants: Chemistry, Pharmacology, and Therapeutic Applications 79-102. CRC Press, Taylor and Francis Group.

Panneerselvam, L., Raghunath, A., Sundarraj, K., Perumal, E. (2018). HO-1/HSP32 and cardiac stress signaling. In: A.A.A. Asea, P. Kaur (eds.). Heat Shock Proteins in Signaling Pathways Vol. 17, 139-160. Springer International Publishing AG.

Raghunath, A., Panneerselvam, L., Sundarraj, K., Perumal, E. (2018). Heat shock proteins and endoplasmic reticulum stress. In: A.A.A. Asea, P. Kaur (eds.). Heat Shock Proteins and Stress Vol. 15, 39-78. Springer International Publishing AG.

Raghunath, A., Perumal, E. (2018). Analysis of lethalith and malformations during zebrafish (Danio rerio) development. In: Luis Felix (ed.). Teratogenicity Testing: Methods and Protocols, Methods in Molecular Biology Vol. 1997, 337-363. Humana Press, New York, NY.

Raghunath, A., Sundarraj, K., Kanagaraj, V.V., Perumal, E. (2018). Plant sources as potential therapeutics for Alzheimer's disease. In: Parimelazhagan Thangaraj (ed.). Medicinal Plants: Promising Future for Health and New Drugs 162-192. CRC Press, Taylor and Francis Group.

Subramaniam, A., Shanmugam, M.K., Perumal, E., Nachiyappan, A., Kumar, A.P., Tan, B. K. H., Sethi, G. (2014). Possible involvement of signal transducer and activator of transcription-3 (STAT3) signaling pathway in the initiation and progression of hepatocellular carcinoma. In: R. Sudhakaran P. (eds). Perspectives in Cancer Prevention-Translational Cancer Research 73-87. Springer, New Delhi.

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